Buffalo's Dominic Johnson, right, and Brock Bertram celebrate after Buffalo upset Arizona 89-68 in first-round game in the NCAA men's college basketball tournament Thursday, March 15, 2018, in Boise, Idaho. (AP Photo/Ted S. Warren)

Ted S. Warren/Associated Press

The Buffalo Bulls sure know how to earn their first NCAA tournament victory in school history in style.

Buffalo, the No. 13 seed in the South Region of the 2018 men’s NCAA tournament, destroyed the fourth-seeded Arizona Wildcats in Thursday’s first-round matchup 89-68. It was a stunning result for the Pac-12 regular-season and tournament champions, cutting short a tournament run many envisioned would last well into the later rounds.

Twitter naturally reacted to the shocker:

Buffalo largely used a three-man effort as Wes Clark (25 points and seven assists), Jeremy Harris (23 points and seven rebounds) and CJ Massinburg (19 points and six boards) were far too much for the Wildcats.

The combination also outshined potential No. 1 pick Deandre Ayton, who put up a solid but unspectacular 14 points and 13 boards for the Wildcats in defeat.

CBS Sports noted the result busted plenty of brackets:

This was an especially painful loss for Arizona as it is entangled in the ongoing FBI investigation into corruption in college basketball, and the on-court games are no longer there to distract the fanbase following Thursday’s loss.

The FBI was fresh on the minds of some after the upset:

This was not only a failure for Arizona but the entire Pac-12 conference seeing how Arizona State and UCLA each lost in the First Four games. The league doesn’t have a single team remaining in the 2018 NCAA tournament, and the first round wasn’t even half over at the end of the Wildcats’ loss.

ESPN Stats & Info and Jeff Eisenberg of Yahoo Sports put things into perspective for the conference:

Things aren’t looking up for the Wildcats moving into the future, either:

Here is a look at the best of the rest of some of the reactions:

Buffalo now turns its attention toward a showdown with the fifth-seeded Kentucky Wildcats in the second round of the tournament.

If it is going to keep its Cinderella run alive, it will once again have to beat one of the best programs in college basketball history. John Calipari‘s squad looked up for the challenge during a tight victory over Davidson on Thursday.

However, if the Bulls drill 15 three-pointers again like they did against Arizona and swarm the Wildcats on the defensive side, they could find themselves in the Sweet 16 as tournament darlings.